Eminem topped the nominations with ten, including Record of The Year, Song of the Year and Album of The Year followed by Bruno Mars who received seven nominations; Jay-Z, Lady Antebellum, and Lady Gaga each earned six nominations; Jeff Beck, B.o.B, David Frost, Philip Lawrence, John Legend and The Roots received five each; Alex Da Kid, The Black Keys, Drake, Cee Lo Green, Ari Levine, Katy Perry, Rihanna, Dirk Sobotka, and Zac Brown each earned four nods; Arcade Fire, Chris Brown, Muse, Miranda Lambert, John Mayer and Alicia Keys each earned three nods; and Robert Plant, Pink, Beyoncé, Justin Bieber, Mumford & Sons, Monica , La Roux, Goldfrapp, Janelle Monáe, Sade, Michael Bublé, Fantasia, Hayley Williams and The White Stripes all received two nominations.
On January 13, 2011, the following were officially announced to perform at the ceremonies:
- Arcade Fire
- Eminem
- Cee Lo Green
- Lady Gaga - Born This Way
- Miranda Lambert
- Katy Perry & Snoop Dogg - California Gurls
- B.o.B
- Lady Antebellum
- Bruno Mars
- Janelle Monáe
- Muse
- Usher and Justin Bieber with Jaden Smith
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